Source: Interfolio F180
Yuzhong Liu, PhD
Research Focus
Natural and unnatural glycosides for novel drug discovery
Glycosylated natural products hold high promise in the development of small molecule drugs due to their innate antimicrobial, antitumor, and immunological activities.
However, glycosides remain vastly underexplored in the context of medicinal chemistry, where the lack of a detailed structure-function relationship precludes the correlation of sugar substituents to biological activity.
This limitation is rooted in the low abundance of naturally occurring glycosides, as well as in the lack of effective synthetic chemical tools for their (glyco)diversification.
Education
Ph.D. University of California, BerkeleyProfessional Experience
2023-Present Assistant Professor, Scripps ResearchSelected Publications
Zhan, Chunjun; Lee, Namil; Lan, Guangxu; Dan, Qingyun; Cowan, Aidan; Wang, Zilong; Baidoo, Edward E K; Kakumanu, Ramu; Luckie, Bridget; Kuo, Rita C.; McCauley, Joshua; Liu, Yuzhong; Valencia, Luis; Haushalter, Robert W.; Keasling, Jay D. Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition. 2023, 5, 1127-1140.
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Cruz-Morales, Pablo; Yin, Kevin; Landera, Alexander; Cort, John R.; Young, Robert P.; Kyle, Jennifer E.; Bertrand, Robert; Iavarone, Anthony T.; Acharya, Suneil; Cowan, Aidan; Chen, Yan; Gin, Jennifer W.; Scown, Corinne D.; Petzold, Christopher J.; Araujo-Barcelos, Carolina; Sundstrom, Eric; George, Anthe; Liu, Yuzhong; Klass, Sarah; Nava, Alberto A.; Keasling, Jay D. Biosynthesis of polycyclopropanated high energy biofuels. JOULE 2022, 6, 1590-1605.
Liu, Yuzhong; Cruz-Morales, Pablo; Zargar, Amin; Belcher, Michael S.; Pang, B o.; Englund, Elias; Dan, Qingyun; Yin, Kevin; Keasling, Jay D. Biofuels for a sustainable future. CELL 2021, 184, 1636-1647.
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Pei, Xiaokun; Bürgi, Hans- B.; Kapustin, Eugene A.; Liu, Yuzhong; Yaghi, O M. Coordinative Alignment in the Pores of MOFs for the Structural Determination of N-, S-, and P-Containing Organic Compounds Including Complex Chiral Molecules. 2019, 141, 18862-18869.
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Liu, Yuzhong; Ma, Yanhang; Yang, Jingjing; Diercks, Chri S.; Tamura, Nobumichi; Jin, Fangying; Yaghi, O M. Molecular Weaving of Covalent Organic Frameworks for Adaptive Guest Inclusion. 2018, 140, 16015-16019.
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Liu, Yuzhong; Ma, Yanhang; Zhao, Yingbo; Sun, Xixi; Gandara, Felipe; Furukawa, Hiroyasu; Liu, Zheng; Zhu, Hanyu; Zhu, Chenhui; Suenaga, Kazutomo; Oleynikov, Peter; Alshammari, Ahmad S.; Zhang, Xiang; Terasaki, Osamu; Yaghi, Omar M. Weaving of organic threads into a crystalline covalent organic framework. SCIENCE 2016, 351, 365-369.
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