Source: Interfolio F180
Darrell Irvine, PhD
Research Focus
The Irvine Lab aims to collaborate across immunology, microbiology and other areas to engage with translational science opportunities, particularly around infectious disease and cancer. A major effort of Dr. Irvine's laboratory at Scripps will be directed toward vaccine development for HIV and cancer immunotherapy.
Engineering strategies directed toward problems in cellular immunology can lead to treatments for cancer, infectious diseases and autoimmune conditions. The Irvine lab aims to achieve this by integrating principles from immunology with biotechnology and materials chemistry. Specifically, Dr. Irvine applies engineering principles to modulate and empower the immune system in the prevention and treatment of human diseases. For example, his lab is developing synthetic materials (smart materials and nanotechnology) to enhance vaccines against infectious disease and cancer, as well as materials that can help improve anti-tumor immune responses.
Education
Ph.D., Polymer Science, Massachusetts Institute of Technology, Cambridge, MAProfessional Experience
2008-present: Investigator, Howard Hughes Medical Institute
2024-present: Vice Chair, Scripps Research Institute, Department of Immunology & Microbiology
2024-present: Professor, Scripps Research Institute, Department of Immunology & Microbiology
2017-2024: Associate Director, Koch Institute for Integrative Cancer Research
2012-2024: Professor, Dept. of Biological Engineering and Dept. of Materials Science & Eng., MIT
2009-2024: Steering Committee, Ragon Institute of MGH, MIT, and Harvard
2007-2024: Faculty, Koch Institute for Integrative Cancer Research
2012-2018: Director, Program in Polymers and Soft Matter, MIT
2002-2006: Assistant Professor, Dept. of Biological Engineering and Dept. of Materials Science & Eng., MIT 2006-2012 Eugene Bell Associate Professor
2000-2002: Postdoctoral fellow, HHMI/Dept. of Microbiol. & Immunology, Stanford Medical School
1995-2000: Graduate Research Asst., Dept. of Materials Sci. & Eng., Massachusetts Inst. of Tech.
Awards & Professional Activities
1995 Graduate Fellow National Science Foundation
2000 Postdoctoral Fellow Damon Runyon-Walter Winchell Foundation
2002 Karl Van Tassel Career Development Professorship in Biomedical Engineering
2003 Young Investigator award Beckman Foundation
2004 CAREER award National Science Foundation
2004 Technology Review ‘TR100’ award
2005 Eugene Bell Career Development Professorship
2006 Young Investigator award Human Frontier Science Program
2006 Jones Lecture on Technology and Society Dartmouth University
2008 Investigator Howard Hughes Medical Institute
2011 Dave Memorial Lecturer Roswell Park Memorial Cancer Institute
2012 Fellow Biomedical Engineering Society
2014 Standing Member, NANO study section NIH
2015 Gerhard Closs Memorial Lecturer University of Chicago
2015 Fellow American Inst. for Medical and Biological Engineering
2015 Ralph M. Steinman Memorial Lecturer Trudeau Institute
2016 Bortree Lecturer Pennsylvania State University
2017 Shu Chien Lecturer, Univ. of California systemwide Bioengineering Annual Symposium
2017 Underwood-Prescott Professor of Biological Engineering
2021 NIH MERIT award