Source: Interfolio F180
Michael Bollong, PhD
Research Focus
Using high throughput small molecule screens coupled with downstream target identification experiments, we identify new drug-like molecules and ligandable targets to study and to therapeutically target the biological responses governing mammalian regeneration and cell stress signaling. We complement these efforts with an additional focus on developing new high throughput and molecular diversity-based methods to accelerate biological discovery. To this end, we are developing platforms for profiling inhibitor-enzyme interactions en masse, deconvoluting the cellular targets for bioactive small molecules and peptides, and leveraging the chemical diversity present in existing chemical libraries as a source of new reactivity for covalent inhibitor design.
Education
Ph.D. (Chemical Biology), Scripps Research, 2016B.S. (Biochemistry and Cell Biology), University of California, San Diego, 2009
Professional Experience
2017-2020 Scripps Fellow, Chemistry, Scripps Research2020-2023 Assistant Professor, Chemistry, Scripps Research
2023-Present Associate Professor, Chemistry, Scripps Research
Awards & Professional Activities
2020 Baxter Foundation Young Faculty Award2022 Philip S. Portoghese Joint Lectureship Award
2023 Amgen Young Investigator Award
2024 The David W. Robertson Award for Excellence in Medicinal Chemistry
Selected Publications
Shao, Sida; Zhang, Nan; Specht, Gregory P.; You, Shaochen; Song, Lirui; Fu, Qiangwei; Huang, David; You, Hengyao; Shu, Jian; Domissy, Alain; Li, Shuangwei; Nguyen-Tran, Van; Joseph, Sean B.; Chatterjee, Arnab K.; Chen, Jeffrey Jia J.; Schultz, Peter G.; Bollong, Michael J. Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair. Proceedings of the National Academy of Sciences of the United States of America 2024, 121, e2400077121.
Ibrahim, Lara; Stanton, Caroline; Nutsch, Kayla; Nguyen, Thu; Li-Ma, Chloris; Ko, Yeonjin; Lander, Gabriel C.; Wiseman, R Luk L.; Bollong, Michael J. Succinylation of a KEAP1 sensor lysine promotes NRF2 activation. Cell chemical biology 2023, 30, 1295-1302.e4.
Stanton, Caroline; Sun, Jie; Nutsch, Kayla; Rosarda, Jessica D.; Nguyen, Thu; Li-Ma, Chloris; Njomen, Evert; Melillo, Bruno; Kutseikin, Sergei; Saez, Enrique; Cravatt, Benjamin F.; Teijaro, John R.; Wiseman, R Luk L.; Bollong, Michael J. Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 2024, 19, 254-265.
Grzelak, Edyta M.; Elshan, N G R Dayan; Shao, Sida; Bulos, Maya L.; Joseph, Sean B.; Chatterjee, Arnab K.; Chen, Jian Jeffrey J.; Nguyên-Trân, Vân; Schultz, Peter G.; Bollong, Michael J. Pharmacological YAP activation promotes regenerative repair of cutaneous wounds. Proceedings of the National Academy of Sciences of the United States of America 2023, 120, e2305085120.
Bollong, Michael J.; Camargo, Fernando D.; Chadwick, Stormi R.; Chatterjee, Arnab; Chen, Emily I.; DeRan, Michael; Grzelak, Edyta M.; Hull, Mitchell V.; Iaconelli, Jonathan; Ibrahim, Lara; Li, Sijia; Nutsch, Kayla; Schultz, Peter G.; Shalhout, Sophia Z.; Shao, Sida; Shen, Weijun; Stanton, Caroline; Wu, Xu; Yang, Peng-Yu; Zambaldo, Claudio YAP-dependent proliferation by a small molecule targeting annexin A2. Nature Chemical Biology 2021.
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Zambaldo, Claudio; Vinogradova, Ekaterina V.; Qi, Xiaotian; Iaconelli, Jonathan; Suciu, Radu M.; Koh, Minseob; Senkane, Kristine; Chadwick, Sto R.; Sanchez, Brittany B B.; Chen, Ja S.; Chatterjee, Arnab K.; Liu, Peng; Schultz, Peter G.; Cravatt, Benjamin F.; Bollong, Michael J. 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. Journal of the American Chemical Society 2020, 142, 8972-8979.
Bollong, Michael J.; Lee, Gihoon; Coukos, John S.; Yun, Hwayoung; Zambaldo, Claudio; Chang, Jae W.; Chin, Emily N.; Ahmad, Insha; Chatterjee, Arnab K.; Lairson, Luke L L.; Schultz, Peter G.; Moellering, Raymond E. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature 2018, 562, 600-604.