Research Themes
The major long-term themes in my research are:
- The understanding of how the amino acid sequence of a protein determines its final folded structure.
- The understanding of enzyme and protein function through study of structure and dynamics.
- These themes are tied together by the phenomenon of intrinsic protein disorder – a number of proteins are not structured in isolation, but fold upon binding to partners. Intrinsic disorder allows versatile interactions with different partners, as well as highly specific and high-affinity interaction that is nevertheless reversible. IDPs frequently function in cellular signaling systems.
Primary research techniques include NMR spectroscopy for study of structure and dynamics, mass spectrometry, and equilibrium and kinetic CD and fluorescence spectroscopy.
Selected publications
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Our favorite molecule
Myoglobin according to Brian Hudson
Role of Intrinsic Protein Disorder in the Function and Interactions of Proteins
Schematic diagram of the domain structure of CBP showing binding sites of proteins that are mentioned in the published review
Structural characterization of a ternary complex
Plots of the weighted average chemical shift differences between corresponding cross-peaks in the spectra of two different protein complexes.
Classic Analysis of Biopolymer Dynamics Is Model Free
Schematic illustration of the dynamic amplitudes of motion for 13C-1H vectors within a macromolecule
