Eubanks LM, Pholcharee T, Oyen D, Natori Y, Zhou B, Wilson IA, Janda KD , "An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression"
ACS Chem Neurosci, (2023)

Park H, Lin M, Zhou J, Eubanks LM, Zhou B, Janda KD , "Development of a Vaccine against the Synthetic Opioid U-47700"
Front Pharmacol, 14, 1219985 (2023)

Richardson RS, Sulima A, Rice KC, Kucharczk JA, Janda KD, Nisbett KE, Koob GF, Vendruscolo LF, Leggio L., "Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice."
Neuropharmacology, 238, 109643 (2023)

Lin M, Eubanks LM, Karadkhelkar NM, Blake S, Janda KD, "Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression"
ACS Pharmacol Transl Sci, 6, 5 (2023)

Karadkhelkar N.M., Lin M., Eubanks L.M., Janda K.D., "Demystifying the Druggability of the MYC Family of Oncogenes"
J. Am. Chem. Soc., 145, 3259 (2023)

Lin, L., Patel, E.N., Nielsen, A.L., Turner, L.D., Tepp, W.H., Nguyen, K., Pellett, S., Janda, K.D., "Transformation of a metal chelate into a “catch and anchor” inhibitor of Botulinum A protease"
Int J Mol Sci , 24(5), 4303 (2023)

Lee, J.C., Eubanks, L.M., Zhou, B., Janda, K.D., "Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin"
ACS Cent. Sci., 8, 1464 (2022)

Lin M., Marin A., Ellis B., Eubanks L.M., Andrianov A.K., Janda K.D., "Polyphosphazene: A New Adjuvant Platform for Cocaine Vaccine Development"
Mol. Pharm., 19, 3358 (2022)

Patel E.N., Lin L., Sneller M.M., Eubanks L.M., Tepp W.H., Pellett S., Janda K.D., "Investigation of Salicylanilides as Botulinum Toxin Antagonists"
ACS Infect. Dis., 8, 1637 (2022)

Patel E.N., Turner L.D., Hixon M.S., Janda K.D., "Identification of Slow-Binding Inhibitors of the BoNT/A Protease"
ACS Med. Chem. Lett., 13, 742 (2022)

Blake S., Shaabani N., Eubanks L.M., Maruyama J., Manning J.T., Beutler N., Paessler S., Ji H., Teijaro JR Janda, K.D., "Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model"
ACS Infect. Dis., 7, 2229 (2021)

Lee, J.C., Park, H., Eubanks, L.M., Ellis, B., Zhou, B., Janda, K.D., "A vaccine against benzimidazole-derived new psychoactive substances that are more potent than fentanyl"
J. Med. Chem., 65, 2522 (2022)

Lee, J.C., Janda, K.D., "Development of effective therapeutics for polysubstance use disorders"
Current Opinion in Chemical Biology, 66, 102105 (2022)

Staples, M.C., Herman, M.A., Lockner, J.W., Avchulumov, Y., Kharidia, K.M., Janda, K.D., Roberto, M., Mandyam, C.D., "Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats"
J. Neurosci. Res., 99, 3047 (2021)

Shirey, R.J., Turner, L.D., Lairson, L.L., Janda, K.D., "Modulators of immunoregulatory exonuclease PLD3 and PLD4 identified by high-throughput screen"
Bioorg. Med. Chem. Lett., 49, 128293 (2021)

Turner, L.D., Nielsen, A.L., Lin, L., Campedelli, A.J., Silvaggi, N.R., Chen, J.S., Wakefield, A.E., Allen, K.N., Janda, K.D., "Use of crystallography and molecular modeling for the inhibition of the Botulinum neurotoxin A protease"
ACS Med. Chem. Lett., 12, 1318 (2021)

Lin, M., Ellis, B., Eubanks, L.M., Janda, K.D., "Pharmacokinetic approach to combat the synthetic cannabinoid PB-22"
ACS Chem. Neurosci., 12, 2573 (2021)

Shirey, R.J., Hart, J.R., Sridharan, B.P., Novick, S.J., Turner, L.D., Zhou, B., Nielsen, A.L., Eubanks, L.M., Ueno, L., Hixon, m.s., Lairson, L.L., Spicer, T.P., Scampavia, L.D., Griffen, P.R., Vogt, P.K., Janda, K.D., "Synthetic fluorescent MYC probe: inhibitor binding site elucidation and development of a high-throughput screening assay"
Bioorg. & Med. Chem., 42, 116246 (2021)

Park, H., Lee, J.C., Eubanks, L.M., Ellis, B., Zhou, B., Janda, K.D., "Improvements on a chemically contiguous hapten for a vaccine to address fentanyl-contaminated heroin"
Bioorg. Med. Chem., 41, 116225 (2021)

Turner, L.D., Nielsen, A.L., Lin, L., Pellet, S., Sugane, T., Olson, M.E., Johnson, E.A., Janda, K.D., "Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach"
RSC Med. Chem., 12, 960 (2021)

Belz, T.F., Lin, M., Eubanks, L.M., Ellis, B., Janda, K.D., "Vaccine design through transition state mimicry of heroin hydrolysis"
Tetrahedron, 71, 153045 (2021)

Rayo, J., Gregor, R., Jacob, N.T., Dandela, R., Dubinsky, L., Yashkin, A., Aranovich, A., Thangara, M., Ernst, O., Barash, E., Malitsky, S., Florea, B.I., Krom, B.P., Wiemer, E.A.C., Kickhoefer, V.A., Rome, L.H., Mthison, J.C., Kaufmann, G.F., Overkleeft, H.S., Cravatt, B.F., Zor, T., Janda, K.D., Ulevitch, R.J., Kravchenko, V.V., Meijler, M.M., "Immunediting role for majoe vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones"
PNAS, 118(12), e2012529118 (2021)

Eubanks, L.M., Blake, S., Natori, Y., Ellis, B., Bremer, P.T., Janda, K.D., "A highly efficacious carfentanil vaccine that blunts opioid-induced antinociception and respiratory depression"
ACS Chem. Bio., 16, 277 (2021)

Lin, M., Lee, J.C., Blake, S., Ellis, B., Eubanks, L.M., Janda, K.D., "Broadly neutralizing synthetic cannabinoid vaccines"
JACS Au, 1, 31 (2021)

Blake, S., Bremer, P., Zhou, B., Petrovsky, N., Smith, L., Hwang, C., Janda, K.D., "Developing translational vaccines against heroin and fentanyl through investigation of adjuvants and stability"
Molecular Pharmaceutics, 18, 228 (2021)

Lin, L., Turner, L.D., Silhar, P., Pellett, S., Johnson, E.A., Janda, K.D., "Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A"
RSC Medicinal Chemistry, 12, 137 (2021)

Belz, T.F., Olson, M.E., Giang, E., Law, M., Janda, K.D., "Evaluation of a series of lipidated tucaresol adjuvants in a hepatitis C virus vaccine model"
ACS Med. Chem. Lett., 11, 2428 (2020)

Townsend, E.A., Bremer, P.T., Negus, S.S., Janda, K.D., Banks, M.L., "A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys"
Drug Alcohol Depend., 218, 108348 (2021)

Lee, J.C., Janda, K.D., "Immunopharmacotherapeutic advancements in addressing methamphetamine abuse"
RSC Chem. Bio., 2, 77 (2021)

Natori, Y., Janda, K.D., "Synthesis of drug vaccine against heroin contaminated with fentanyl and their biological evaluation"
J. Synth. Org. Chem. Jpn., 78(9), 875 (2020)

Lin. L., Olson, M.E., Sugane, T., Turner, L.D., Tararina, M.A., Nielsen, A.L., Kurbanov, E.K., Pellet, S., Johnson, E.A., Cohen, S.M., Allen, K.N., Janda, K.D., "Catch and anchor approach to combat both toxicity and longevity of BotulimumToxin A"
J. Med. Chem., 63, 11100 (2020)

Townsend, E.A., Bremer, P., Faunce, K., Negus, S.S., Jaster, A., Robinson, H., Janda, K.D., Banks, M.L., "Evaluation of a dual fentanyl/heroin vaccine on the antinociceptive and reinforcing effects of a fentanyl/heroin mixture in male and female rats"
ACS Chem. Neurosci., 11, 1300 (2020)

Belz, T., Bremer, P., Zhou, B., Ellis, B., Eubanks, L.M., Janda, K.D., "Enhancement of a heroin vaccine through hapten deuteration"
J. Amer. Chem. Soc., 142, 13294 (2020)

Lee, J.C., Kim, H.Y., Lee, S., Shin, J., Kim, H.V., Kim, K., Baek, S., Lee, D., Jeon, H., Kim, D., Yang, S-H., Han, G., Park, K., Choi, J., Park, J., Moss, J.M., Janda, K.D., Kim, Y. , "Discovery of chemicals to either clear or indicate amyloid aggregates by targeting memory-impairing anti-parallel Aß dimers"
Angew. Chem. Int. Ed., 59, 11491 (2020)

Belz, T.F., Bremer, P.T., Zhou, B., Blake, S., Ellis, B., Eubanks, L.M., Janda, K.D., "Sulfonate-isoteric replacement examined within heroin-hapten vaccine design"
Bioorg. & Med. Chem. Lett., 30, 127388 (2020)

Blake, S., Thanissery, R., Rivera, A.J., Hixon, M.S., Lin, M., Theriot, C.M., Janda, K.D., "Salicylanilide analog minimizes relapse of Clostridioides difficile infection in mice"
J. Med. Chem., 63, 6898 (2020)

Wang, J., Ellis, B.A., Zhou, B., Eubanks, L.M., Blake, S., Janda, K.D., "A fentanyl vaccine constructed upon opsonizing antibodies specific for the GaLα1-3Gal epitope"
Chem. Commun., 56, 6551 (2020)

Janda, K.D., Iadarola, M.J., "Standing out from the crowd in treating COVID-19"
Medicine in Drug Discovery, 6, 100034 (2020)

Lin, L., Olson, M.E., Eubanks, L.M., Janda, K.D., "Strategies to contract Botulinum Neurotoxin A: Nature's deadliest biomolecule"
Acc. Chem. res., 52, 2322 (2019)

Olson, M.E., Sugane, T. Zhou, B., Janda, K.D., "Consequence of happen stereochemistry: An efficacious methamphetamine vaccine"
J. Amer. Chem. Soc., 141, 14089 (2019)

Tenney, R.D., Blake, S., Bremer, P.T., Zhou, B., Hwang, C.S., Poklis, J.L., Janda, K.D., Banks, M.L., "Vaccine blunts fentanyl potency in male rhesus monkeys"
Neuropharmacology, 158, 107730 (2019)

Smith, L.C., Bremer, P.T., Hwang, C.S., Zhou, B., Ellis, B., Hixon, M.S., Janda, K.D., "Monoclonal antibodies for combating synthetic opioid intoxication"
J. Amer. Chem. Soc., 141, 10489 (2019)

Hwang, C.S., Smith, L.C., Wenthur, C.J., Ellis, B., Zhou, B., Janda, K.D., "Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences"
Vaccine, 37, 4155 (2019)

Natori, Y., Hwang, C.S., Lin, L., Smith, L.C., Zhou, B., Janda, K.D., "A chemically contiguous hasten approach for a heroin-fentanyl vaccine"
Beilstein J. Org. Chem., 15, 1020 (2019)

Townsend, E.A., Blake, S., Faunce, K.E., Hwang, C.S., Natori, Y., Zhou, B., Bremer, P.T., Janda, K.D., Banks, M.L., "Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats"
Neuropsychopharmacoloy, 44, 1681 (2019)

Nguyen, J.D., Grant, Y., Creehan, K.M., Hwang, C.S., Vanderwater, S.A., Janda, K.D., Cole, M., Taffe, M.A., "∆9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions"
Neuropharmacology, 151, 127 (2019)

Wenthur, C.J., Gautam, R., Zhou, B., Vendruscolo, L.F., Leggio, L., Janda, K.D., "Ghrelin receptor influence on cocaine reward is not directly dependent on peripheral acyl-ghrelin"
Nature Scientific Reports, 9, 1841 (2019)

Wang, J., Merino, D.M., Light, N., Murphy, B.L., Wang, Y-D, Guo, X., Hodges, A.P., Chau, L.Q., Liu, K-W, Dhali, G., Asgharzadeh, S., Kiehna, E.N., Shirey, R.J., Janda, K.D., Taylor, M.D., Malkin, D., Ellison, D.W., VandenBerg, S.R., Eberhart, C.G., Sears, R.C., Roussel, M.F., Gilbertson, R.J., Wechsler-Reya, R.J., "Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma"
Cancer Res., 79(9), 2208 (2018)

Banks, M.L., Olson, M.E., Janda, K.D., "Immunopharmacotherapies for treating opioid use disorder"
Trends Pharmacol. Sci., 39(11), 908 (2018)

Kallupi, M., Xue, S., Zhou, B., Janda, K.D., George, O., "An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse"
Sci. Adv., 4(10), 4751 (2018)

Olson, M.E., Eubanks, L.M., Janda, K.D., "Chemical interventions for the opioid crisis: Key advances and remaining challenges"
J. Am. Chem. Soc., 141, 1798 (2019)

Hwang, C.S., Ellis, B., Zhou, B., Janda, K.D., "Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin"
Bioorg. & Med. Chem., 27, 125 (2018)

Smith, L.C., Lin, L., Hwang, C.S., Zhou, B., Kubitz, D.M., Wang, H., Janda, K.D., "Lateral flow assessment and unanticipated toxicity of krater"
Chem. Res. Tox., 32, 113 (2019)

Shirey, R.J., Globisch, D., Eubanks, L.M., Hixon, M.S., Janda, K.D., "Noninvasive urine biomarker lateral flow immunoassay for monitoring active Onchocerciasis"
ACS Infect. Dis., 4, 1423 (2018)

Hwang, C.S., Smith, L.C., Natori, Y., Ellis, B., Zhou, B., Janda, K.D., "Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin"
ACS Omega, 3, 11537 (2018)

Jacob, N.T., Miranda, P.O., Shirey, R.J., Gautam, R., Zhou, B., de Orbe Izquierdo, M.E., Hixon, M.S., Hart, J.R., Ueno, L., Vogt, P.K., Janda, K.D., "Synthetic molecules for disruption of the MYC protein-protein interface"
Bioorg. & Med. Chem., 26, 4234 (2018)

Nguyen, J.D., Hwang, C.S., Grant, Y., Janda, K.D., Taffe, M.A., "Prophylactic vaccination protects against the development of oxycodone self-administration"
Neuropharmacology, 138, 292 (2018)

Taraina, M.A., Xue, S., Smith, L.C., Muellers, S.N., Miranda, P.O., Janda, K.D., "Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme"
Biochemistry, 57, 3741 (2018)

Hwang, C.S., Smith, L.C., Natori, Y., Ellis, B., Zhou, B., Janda, K.D., "Efficacious vaccine against heroin contaminated with fentanyl"
ACS Chem. Neurosci., 9(6), 1269 (2018)

Kimishima, A., Olson, M.E., Natori, Y., Janda, K.D., "Efficient syntheses of cocaine vaccines and their in vivo evaluation"
ACS Med. Chem. Lett., 9(5), 411 (2018)

Miranda, P.O., Cubitt, B., Jacob, N.T., Janda, K.D., Carlos de la Torre, J., "Mining a Kröhnke pyridine library for anti-arenavirus activity"
ACS Infec. Dis., 4(5), 815 (2018)

Hwang, C.S., Bremer, P.T., Wenthur, C.J., Ho, S.O., Chiang, S., Ellis, B., Zhou, B., Fujii, G., Janda, K.D., "Enhancing efficacy and stability of an antiheroin vaccine: Examination of antinociception, opioid binding profile, and lethality"
Mol. Pharmaceutics, 15(3), 1062 (2018)

Olson, M.E., Janda, K.D., "Vaccines to combat the opioid crisis"
EMBO reports, 19(1), 5 (2018)

Kimishima, A., Olson, M.E., Janda, K.D., "Investigations into the efficacy of multi-component cocaine vaccines"
Bioorg. Med. Chem. Lett., 28, 2779 (2018)

Xue, S., Kallupi, M., Zhou, B., Smith, L.C., Miranda, P.O., George, O., Janda, K.D., "An enzymatic advance in nicotine cessation therapy"
Chem. Commun., 54(14), 1686 (2018)

Xue, S., Seki, H., Remes, M., Silhar, P., Janda, K., "Examination of alpa-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicory acid"
Bioorg. Med. Chem. Lett., 27, 4956 (2017)

Hwang, C.S., Janda, K.D., "A vision for vaccines: Combating the opioid epidemic"
Biochemistry, 56(42), 5625 (2017)

Wenthur, C.J., Zhou, B., Janda, K.D., "Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity"
Nature, 548, 476 (2017)

Wenthur, C.J., Cai, X., Ellis, B.A., Janda, K.D., "Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric happen design and combinatorial vaccination"
Bioorg. Med. Chem. Lett., 27(16), 3666 (2017)

Globisch, D., Eubanks, L.M., Shirey, R.J., Pfarr, K.M., Wanji, S., Debrah, A.Y., Hoerauf, A., Janda, K.D., "Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG)"
Bioorg. Med. Chem. Lett., 27(15), 3426 (2017)

Kimishima, A., Wenthur, C.J., Zhou, B., Janda, K.D., "An advance in prescription opioid vaccines: Overdose mortality reduction and extraordinary alteration of drug half-life"
ACS Chem. Biol., 12, 36 (2017)

Taraina, M.A., Janda, K.D., Allen, K.N., "Structural analysis provides mechanistic insight into nicotine oxidoreductase from Pseudomonas putida"
Biochemistry, 55, 6595 (2016)

Jacob, N.T., Anraku, K., Kimishima, A., Zhou, B., Collins, K.C., Lockner, J.W., Ellis, B.A., Janda, K.D., "A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior"
Chem. Commun., 53(58), 8156 (2017)

Bremer, P.T., Janda, K.D., "Conjugate vaccine immunotherapy for substance use disorder"
Pharmacological Review, 69(3), 298 (2017)

Bremer, P.T., Schlosburg, J.E., Banks, M.L., Steele, F.F., Zhou, B., Polkis, J.L., Janda, K.D., "Development of a clinically viable heroin vaccine"
J. Am. Chem. Soc., 139(25), 8601 (2017)

Bremer, P.T., Pellett, S., Carolan, J.P., Tepp, W.H., Eubanks, L.M., Allen, K.N., Johnson, E.A., Janda, K.D., "Metal ions ablate the action of Botulinum Neurotoxin A"
J. Am. Chem. Soc., 139(21), 7264 (2017)

Nguyen, J.D., Bremer, P.T., Hwang, C.S., Vanderwater, S.A., Collins, K.C., Creehan, K.M., Janda, K.D., Taffe, M.A., "Effective active vaccination against methamphetamine in female rats"
Drug & Alcohol Dependence, 175, 179 (2017)

Anraku, K., Sato, S., Jacob, N.T., Eubanks, L.M., Ellis, B.A., Janda, K.D., "The design and synthesis of an alpha-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response"
Org. Biomol. Chem., 15(14), 2979 (2017)

Srinivasulu, V., Janda, K.D., Abu-Yousef, I.A., O'Connor, M.J., Al-Tel, T.H., "A modular CuI-L-proline catalyzed one-pot route for the rapid access of constrained hetero-atom-linked medium-sized ring systems"
Tetrahedron, 73, 2139 (2017)

Mandyam, C., Galinato, M., Lockner, J., Fannon, M., Sobieraj, J., Staples, M., Somkuwar, S., Ghofranian, A., Chaing, S., Navarro, A., Joea, A., Luikart, B., Janda, K.D., Heyser, C., Koob, G., "A synthetic small molecule Isoxazole-9 protects against methamphetamine relapse"
Mol. Psychiatry, 23(3), 629 (2017)

Gooyit, M., Miranda, P.O., Wenthur, C.J., Ducime, A., Janda, K.D., "Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design"
ACS Chemical Neuroscience, 8, 468 (2017)

Bremer, P., Adler, M., Phung, C., Singh, A., Janda, K.D., "Newly designed qunolinol inhibitors mitigate the effects of Botulinum Neurotoxin A in enzymatic, cell-based and ex vivo assays"
J. Med. Chem., 60, 338 (2017)

Nguyen, J.D., Bremer, P.T., Ducime, A., Creehan, K.M., Kisby, B.R., Taffe, M.A., Janda, K.D., "Active vaccination attenuates the psychostimulant effects of alpha-PVP and MDPV in rats"
Neuropharmacology, 116, 1 (2017)

Kimishima, A., Wenthur, C.J., Eubanks, L.M., Sato, S., Janda, K.D., "Cocaine vaccine development: Evaluation of carrier and adjuvant combinations that activate toll-like receptors"
Mol. Pharmaceutics, 13, 3884 (2016)

Evans, S.M., Foltin, R.W., Hicks, M.J., Rosenberg, J.B., De, B.P., Janda, K.D., Kaminsky, S.M., Crystal, R.G., "Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacquisition using a choice procedure in rhesus macaques"
Pharmacology, Biochemistry and Behavior, 150-151, 76 (2016)

Bremer, P.T., Xue, S., Janda, K.D., "Picolinic acids as beta-exosite inhibitors of Botulinum neurotoxin A light chain"
Chem. Commun., 52, 12521 (2016)

Zhou, B., Eubanks, L.M., Jacob, N.T., Ellis, B., Roberts, A.J., Janda, K.D., "Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose"
Bioorg. Med. Chem. Lett., 26, 5078 (2016)

Gooyit, M., Janda, K.D., "Reprofiled anthelmintics abate dormant and hypervirulent Clostridium difficile"
Nature Scientific Report, 6:33642, doi: 10.1038/srep33642 (2016)

Gooyit, M.D., Janda, K.D., "Modulation of the surface-layer protein of Clostridium difficile through Cwp84 inhibition"
ACS Infect. Dis., 2, 465 (2016)

Bremer, P.T., Kimishima, A., Schlosburg, J.E., Zhou, B., Collins, K.C., Janda, K.D., "Combatting synthetic designer opioids: A conjugate vaccine ablates lethal doses of fentanyl class drugs"
Angew. Chem. Int. Ed. Engl., 55, 3772 (2016)

Seki, H., Xue, S., Pellett, S., Silhar, P., Johnson, E.A., Janda, K.D., "Cellular protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of thioredoxin reductase through a suicide substrate mechanism"
J. Am. Chem. Soc., 138, 5568 (2016)

Collins, K.C., Schlosburg, J.E., Bremer, P.T., Janda, K.D., "Methamphetamine vaccines: Improvement through hapten design"
J. Med. Chem., 59, 3878 (2016)

Tsuchikama, K., Gooyit, M., Harris, T.L., Zhu, J., Globisch, D., Kaufmann, G.F., Janda, K.D., "Glycation reactivity of a quorum-sensing signaling molecule"
Angew. Chem., 128, 4070 (2016)

Jacob, N.T., Lockner, J.W., Schlosburg, J.E., Ellis, B.A., Eubanks, L.M., Janda, K.D., "Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development"
J. Med. Chem., 59, 2523 (2016)

Harris, T.L., Wenthur, C.J., Diego-Taboada, A., MacKenzie, G., Corbitt, T.S., Janda, K.D., "Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-Diaminopyridine for treatment of Botulinum neurotoxin A intoxication"
Chem. Comm., 52, 4187 (2016)

Hart, J.R., Weinberg, M.S., Morris, K.V., Roberts, T.C., Janda, K.D., Garner, A.L., Vogt, P.K., "MINCR is not a MYC-induced IncRNA"
PNAS, 113(5), E496 (2016)

Collins, K.C., Janda, K.D., ""Hapten Design for Anti-addiction Vaccine Development""
in Biologics to treat Substance Abuse Disorders; Vaccines, Monoclonal Antibodies, and Enzymes, ed., Ivan D. Montoya, 327-365 (2015)

Globisch, D., Specht, S., Pfarr, K.M., Eubanks, L.M., Hoerauf, A., Janda, K.D., "Litomosoides sigmodontis: A jird urine metabolome study"
Bioorg. Med. Chem. Lett., 25, 5804 (2015)

Collins, K.C., Tsuchikama, K., Lowery, C.A., Zhu, J., Janda, K.D., "Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis"
J. Am. Chem. Soc., 72, 3593 (2016)

Xue, S., Schlosburg, J.E., Janda, K.D., "A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine"
J. Amer. Chem. Soc., 137, 10136 (2015)

Miller, M.L., Aarde, S.M., Moreno, A.Y., Creehan, K.M., Janda, K.D., Taffe, M.A., "Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats"
Drug & Alcohol Dependence, 153, 29 (2015)

Cai, X., Globisch, D., Thompson, P., Lin, J., Toader, D., Dimasi, N., Gao, C., Janda, K.D., "A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates"
Tetrahedron Lett., 56, 3172 (2015)

Zhu, J., Cai, X., Harris, T.L., Gooyit, M., Wood, M., Lardy, M., Janda, K.D., "Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model"
Chemistry & Biology, 22, 483 (2015)

Gooyit, M., Harris, T.L., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Onchocerca volvulus molting inhibitors identifeied through scaffold hopping"
ACS Infect. Dis., 1, 198 (2015)

Seki, H., Xue, S., Hixon, M.S., Pellett, S., Remes, M., Johnson, E.A., Janda, K.D., "Toward the discovery of dual inhibitors for botulinum nerotoxin A: concomitant targeting of endocytosis and light chain protease activity"
Chem. Commun., 51, 6226 (2015)

Gooyit, M., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Exploiting the polypharmacology of ß-carbolines to disrupt O. volvulus molting"
ACS Med. Chem. Lett., 6, 339 (2015)

Lockner, J.W., Eubanks, L.M., Choi, J.L., Lively, J.M., Schlosburg, J.E., Collins, K.C., Globisch, D., Rosenfeld-Gunn, R.J., Wilson, I.A., Janda, K.D., "Flagellin as carrier and adjuvant in cocaine vaccine development"
Mol. Pharmaceutics, 12, 653 (2015)

Lockner J.W., Lively, J.M., Collins, K.C., Vendruscolo, J.C.M., Azar, M.R., Janda, K.D., "A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity"
J. Med. Chem., 58, 1005 (2015)

Xue, S., Javor, S., Hixon, M.S., Janda, K.D., "Probing BoNT/A protease exosites: Implications for inhibitor design and light chain longevity"
Biochemistry, 53, 6820 (2014)

Hart, J.R., Garner, A.L., Yu, J., Ito, Y., Sun, M., Ueno, L., Rhee, J.-K., Baksh, M., Stefan, E., Hartl, M., Bister, K., Vogt, P.K., Janda, K.D., "Inhibitor of MYC identified in a Krohnke pyridine library"
PNAS, 111(34), 12556 (2014)

Raffeiner, P., Rock, R., Schraff, A., Hartl, M., Hart, J.R., Janda, K.D., Vogt, P.K., Stefan, E., Bister, K., "In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential"
Oncotarget, 5(19), 8869 (2014)

Eubanks, L.M., Ellis, B.A., Cai, X., Schlosburg, J.E., Janda, K.D., "A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies"
Bioorg. Med. Chem. Lett., 24, 4664 (2014)

Harris, T.L., Lowery, C.A., Hixon, M.S., Janda, K.D., "A Platform stratifying a sequestering agent and a pharacological antagonist as a means to negate Botulinum neurotoxicity"
ACS Chem. Neurosci., 5, 632 (2014)

Jacob, N.T., Lockner, J.W., Kravchenko, V.V., Janda, K.D., "Pharmacophore reassignment for induction of immunosurveillance cytokine TRAIL"
Angew. Chem. Int. Ed., 53, 6628 (2014)

Hicks, M.J., Kaminsky, S.M., De, B.P., Rosenberg, J.B., Evans, S.M., Foltin, R.W., Andrenyak, D.M., Moody, D.E., Koob, G.F., Janda, K.D., Ricart Arbona, R.J., Lepherd, M.L., Crystal, R.G., "Fate of systematically administered cocaine in nonhuman primates treated with the dAd5GNE anti-cocaine vaccine"
Hum. Gene Ther. Clin. Dev., 25(1), 40 (2014)

Collins, K.C., Schlosburg, J.E., Lockner, J.W., Bremer, P.T., Ellis, B.A., Janda, K.D., "Liquid tucaresol as an adjuvant for methamphetamine vaccine development"
Chem. Commun., 50, 4079 (2014)

Collins, K.C., Janda, K.D., "Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse"
Bioconjugate Chem., 25, 593 (2014)

Bremer, P.T., Hixon, M.S., Janda, K.D., "Benzoquinones as inhibitors of botulinum neurotoxin serotype A"
Bioorg. Med. Chem., 22, 3971 (2014)

Gooyit, M., Tricoche, N., Lustigman, S., Janda, K.D., "Dual protonophore - chitinase inhibitors dramatically affect O. volvulvus molting"
J. Med. Chem., 57, 5792 (2014)

Bremer P.T., Schlosburg, J.E., Lively, J.M., Janda, K.D., "Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy"
Mol. Pharmaceutics, 11, 1075 (2014)

Seki, H., Pellett, S., Silhar, P., Stowe, G.N., Blanco, B., Lardy, M.A., Johnson, E.A., Janda, K.D., "Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain"
Bioorg. Med. Chem., 22, 1208 (2014)

Silhar, P., Eubanks, L.M., Seki, H., Pellett, S., Javor, S., Tepp, W.H., Johnson, E.A., Janda, K.D., "Targeting Botulinum A cellular toxicity: A prodrug approach"
Bioorg. Med. Chem., 56, 7870 (2013)

Lowery, C.A., Adler, M., Borrell, A., Janda, K.D., "Scorpion toxins for the reversal of BoNT-induced paralysis"
Bioorg. Med. Chem. Lett., 23, 6743 (2013)

Cai, X., Whitfield, T.,Moreno, A.Y., Grant, Y., Hixon, M.S., Koob, G.F., Janda, K.D., "Probing the effects of hapten stability on cocaine vaccine immunogenicity"
Mol. Pharm. , 10, 4176 (2013)

Garner, A.L., Fullagar, J.L., Day, J.A., Cohen, S.M., Janda, K.D., "Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors"
J. Am. Chem. Soc., 135, 10014 (2013)

Lowery, C.A., Matamouros, S., Niessen, S., Zhu, J., Scolnick, J., Lively, J.M., Cravatt, B.F., Miller, S.I., Kaufmann, G.F., Janda, K.D., "A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level"
Chemistry & Biology, 20(7), 903 (2013)

Zhu, J., Hixon, M.S., Globisch, D., Kaufmann, G.F., Janda, K.D., "Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation"
J. Am. Chem. Soc., 135(21), 7827 (2013)

Maoz, A., Hicks, M.J., Vallabhjosula, S., Synan, M., Kothari, P.J., Dyke, J.P., Ballon, D.J., Kaminsky, S.M., De, B.P., Rosenburg, J.B., Martinez, D., Koob, G.F., Janda, K.D., Crystal, R.G., "Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter"
Neuropsychopharmacology, 38, 2170 (2013)

Schlosburg, J.E., Vendruscolo, L.F., Bremer, P.T., Lockner, J.W., Wade, C.L., Nunes, A.A., Stowe, G.N., Edwards, S., Janda, K.D., Koob, G.F., "Dynamic vaccine blocks relapse to compulsive intake of heroin"
PNAS, 110(22), 9036 (2013)

Matyas G.R., Mayorov, A.V., Rice, K.C., Jacobson, A.E., Cheng, K., Iyer, M.R., Li, F., Beck, Z., Janda, K.D., Alving, C.R., "Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs"
Vaccine, 31(26), 2804 (2013)

Cai, X., Whitfield, T., Hixon, M.S., Grant, Y., Koob, G.F., Janda, K.D., "Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design"
J. Med. Chem., 56(9), 3701 (2013)

Cai, X., Tsuchikama, K., Janda, K.D., "Modulating cocaine vaccine potency through hapten fluorination"
J. Am. Chem. Soc., 135, 2971 (2013)

Struss, A.K., Nunes, A., Waalen, J., Lowery, C.A., Pullanikat, P., Denery, J.R., Conrad, D.J., Kaufmann, G.F., Janda, K.D., "Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states"
Anal. Chem., 85, 3355 (2013)

De, B.P., Pagovich, O.E., Hicks, M.J., Rosenberg, J.B., Moreno, A.Y., Janda, K.D., Koob, G.F., Worgall, S., Kaminsky, S.M., Sondhi, D., Crystal, R.G., "Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity"
Human Gene Therapy, 24, 58 (2013)

Rosenberg, J.B., De, B.P., Hicks, M.J., Janda, K.D., Kaminsky, S.M., Worgall, S., Crystal, R.G., "Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based anti-nicotine vaccine"
Human Gene Therapy, 24(6), 595 (2013)

Kravchenko V., Garner, A.L., Mathison, J., Seit-Nebi, A., Yu, J., Gileva, I.P., Ulevitch, R., Janda, K.D., "Facilitating cytokine-mediated cancer cell death by proteobacterial N-Acylhomoserine lactones"
ACS Chem. Biol., 8, 1117 (2013)

Globisch, D., Moreno, A.Y., Hixon, M.S., Nunes, A.A.K., Denery, J.R., Specht, S., Hoerauf, A., Janda, K.D., "Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness"
PNAS, 110(11), 4218 (2013)

Fullagar, J.L., Garner, A.L., Struss, A.K., Day, J.A., Martin, D.P., Yu, J., Cai, X., Janda, K.D., Cohen, S.M., "Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase"
Chem. Commun., 49(31), 3197 (2013)

Silhar, P., Lardy, M.A., Hixon, M.S., Shoemaker, C.B., Barbieri, J.Y., Struss, A.K., Lively, J.M., Javor, S., Janda, K.D., "The C-Terminus of Botulinum A protease has profound and unanticipated kinetic consequences upon the catalytic cleft"
Med. Chem. Lett., 4(2), 283 (2013)

Silhar, P., Sivaggi, N.R., Pellett, S., Capkova, K., Johnson, E.A., Allen, K.N., Janda, K.D., "Evaluation of adamantane hydroxymates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies"
Bioorg. Med. Chem., 21, 1344 (2013)

Garner, A.L., Yu, J., Struss, A.K., Kaufmann, G.F., Kravchenko, V.V., Janda, K.D., "Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development"
Chem. Commun., 49, 1515 (2013)

Lockner, J.W., Ho, S.O., McCague, K.C., Chiang, S.M., Do, T.Q., Fujii, G., Janda, K.D., "Enhancing nicotine vaccine immunogenicity with liposomes"
Bioorg. Med. Chem. Lett., 23, 975 (2013)

Bremer, P.T., Janda, K.D., "Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance"
J. Med. Chem., 55, 10776 (2012)

Miller, M.L., Moreno, A.Y., Aarde, S.M., Creehan, K.M., Vanderwater, S.A., Vaillancourt, B.D., Wright, Jr., M.J., Janda, K.D., Taffe, M.A., "A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats"
Biol. Psychiatry, 73, 721 (2013)

von Hoven, G., Kloft, N., Neukirch, C., Ebinger, S., Bobkiewicz, W., Weis, S., Boller, K., Janda, K.D., Husman, M., "Modulation of translation and induction of autophagy by bacterial exoproducts"
Med. Microbiol. Immunol., 201(4), 409 (2012)

Moreno, A.Y., Azar, M.R., Koob, G.F., Janda, K.D., "Probing the protective effects of a conformationally constrained nicotine vaccine"
Vaccine, 30, 6665 (2012)

Hicks, M.J., Rosenberg, J.B., De, B.P., Pagovich, O.E., Young, C.N., Qiu, J., Kaminsky, S.M., Hackett, N.R., Worgall, S., Janda, K.D., Davisson, R.L., Crystal, R.G., "AAV-Directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation"
Science Translational Medicine, 4(140), 140ra87 (2012)

Garner, A.L., Struss, A.K., Fullagar, J.L., Agrawal, A., Moreno, A.Y., Cohen, S.M., Janda, K.D., "3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa virulence factor LasB"
Med. Chem. Lett., 3, 668 (2012)

Kirchdoerfer, R.F., Garner, A.L., Flack, C.E., Mee, J.M., Horswill, A.R., Janda, K.D., Kaufmann, G.F., "Structural basis for ligand recognition and discrimination of a quorum-quenching antibody"
J. Biol. Chem., 286(19), 17351 (2012)

Treweek, J.B., Janda, K.D., "An antidote for acute cocaine toxicity"
Mol. Pharmaceutics, 9(4), 969 (2012)

Zakhari, J.S., Zorrilla, E.P., Zhou, B., Mayorov, A.V., Janda, K.D., "Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice"
Pharmoceutics, 9, 281 (2012)

Globisch, D., Lowery, C.A., McCague, K.C., Janda, K.D., "Uncharacterized 4,5-Dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: Implications for a greater signaling diversity in bacterial species"
Angew. Chem. Int. ed., 51, 4204 (2012)

Rosenberg, J.B., Hicks, M.J., De, B.P., Pagovich, O., Frenk, E., Janda, K.D., Wee, S., Koob, G.F., Hackett, N.R., Kaminsky, S.M., Worgall, S., Tignor, N., Mezey, J.G., Crystal, R.G., "AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that supresses cocaine-induced behavior"
Human Gene Therapy, 23, 451 (2012)

Kravchenko, V.V., Gloeckner, C., Stowe, G.N., Kang, Y.J., Tobias, .S., Mathison, J.C., Ulevitch, R.J., Kaufmann, G.F., Janda, K.D., "The use of small molecule probes to study spatially separated stimulus-induced signaling pathways"
Bioorg. Med. Chem. Lett., 22, 2043 (2012)

Romano, A.A., Hahn, T., Davis, N., Lowery, C.A., Struss, A.K., Janda, K.D., Bottger, L.H., Matznke, B.F., Carrano, C.J., "The Fe(III) and Ga(III) coordination chemistry of a 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules"
Journal of Inorganic Biochemistry, 107, 96 (2012)

Koob, G., Hicks, M.J., Wee, S., Rosenburg, J.B., De, B.P., Kaminsky, S.M., Moreno, A., Janda, K.D., Crystal, R.G., "Anti-cocaine analog to a disrupted adenovirus"
CNS Neurol. Disord. Drug targets, 10(8), 899 (2011)

Janda, K.D., Treweek, J.B., "Vaccines targeting drugs of abuse: is the glass half-empty or half-full?"
Nat. Rev. Immunol., 12(1), 67 (2011)

Stowe, G.N., Schlosburg, J.E., Vendruscolo, L.F., Edwards, S., Misra, K.K., Schulteis, G., Zakhari, J.S., Koob, G.F., Janda, K.D., "Developing a vaccine against multiple psycoactive targets: A case study of heroin"
CNS & Neurological Disorders - Drug Targets , 10, 865 (2011)

LI, Z., Garner, A.L., Gloeckner, C., Janda, K.D., Carlow, C.K., "Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy"
PLoS Neglected Tropical Diseaeses, 5(11), e1411 (2011)

Hoon, S., Zhou, B., Janda, K.D., Brenner, S., Scolnick, J., "Aptamer selection by high-throughput sequencing and informatics analysis"
Biotechniques, 51(6), 413 (2011)

Moreno, A.Y., Janda, K.D., "Current challenges for the creation of effective vaccines against drugs of abuse"
Expert Rev. Vaccines, 10(12), 1637 (2011)

Zakhari, J.S., Kinoyama, I., Hixon, M.S., Di Mola, A., Globisch, D., Janda, K.D., "Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization"
Bioorg. Med. Chem., 19, 6203 (2011)

Eubanks, L.E., Stowe, G.N., De Lamo Marin, S., Mayorov, A.V., Hixon, M.S., Janda, K.D., "Identification of alpha(2) macroglobulin as a major serum ghrelin esterase"
Angew. Chem. Int. Ed. Engl., 50, 10699 (2011)

Wee, S., Hicks, M.J., De, B.P., Rosenberg, J.B., Moreno, A.Y., Kaminsky, S.M., Janda, K.D., Crystal, R.G., Koob, G.F., "Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects"
Neuropsychopharmacology, 1 (2011)

Garner, A.L., Park, J., Zakhari, J.S., Lowery, C.A., Struss, A.K., Sawada, D., Kaufmann, G.F., Janda, K.D., "A multivalent probe for AI-2 quorum sensing receptors"
J. Am. Chem. Soc., 133, 15934 (2011)

Liu, Y., Jiang, P., Capkova, K., Xue, D., Ye, L., Sinha, S.C., Mackman, N., Janda, K.D., Liu, C., "Tissue factor activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy"
Cancer. Res., 71(20), 6492 (2011)

Tsuchikama, K., Lowery, C.A., Janda, K.D., "Probing autoinducer-2 based quorum sensing: the biological consequences of molecules unable to traverse equilibrium states"
J. Org. Chem., 76(17), 6981 (2011)

Stowe, G.N., Vendruscolo, L.F., Edwards, S., Schlosburg, J.E., Misra, K.K., Schulteis, G., Mayorov, A.V., Zakhari, J.S., Koob, G.F., Janda, K.D., "A vaccine strategy that induces protective immunity against heroin"
J. Med. Chem., 54(14), 5195 (2011)

Garner, A.L., Janda, K.D., "A small molecule antagonist of ghrelin O-acyltransferase (GOAT)"
Chem. Commun., 47, 7512 (2011)

Garner, A.L., Gloeckner, C., Trioche, N., Zakhari, J.S., Samje, M., Cho-Ngwa, F., Lustigman, S., Janda, K.D., "Design, synthesis, and biological activities of Closantel analogues: Structural promiscuity and its impact on Onchocerca vovulus"
J. Med. Chem., 54, 3963 (2011)

Moreno, A.Y., Mayorov, A.V., Janda, K.D., "Impact of distant chemical structures for the development of a methamphetamine vaccine"
J. Am. Chem. Soc., 133, 6587 (2011)

Uckun, F.M., Qazi, Z.O., Garner, A.L., Pitt, J., Ma, H., Janda, K.D., "Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signaling network"
British Journal of Haematology, 153, 741 (2011)

Janda, K.D., "Editor's Note"
Bioorg. Med. Chem., 19(1), 20 (2011)

Silhar, P., Alakurtti, S., Capkova, K., Xiaochuan, F., Shoemaker, C.B., Yli-Kauhaluoma, J., Janda, K.D., "Synthesis and evaluation of library of betulin derivitives against the botulinum neurotoxin A protease"
Bioorg. Med. Chem. Lett., 21, 2229 (2011)

Zakhari, J.S., Kinoyama, I., Struss, A.K., Pullanikat, P., Lowery, C.A., Lardy, M., Janda, K.D., "Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum"
J. Am. Chem. Soc., 133(11), 3840 (2011)

Treweek, J.B., Roberts, A.J., Janda, K.D., "Immunopharmacotherapeutic manifolds and modulation of cocaine overdose"
Pharmacol. Biochem. Behav., 98, 474 (2011)

Garner, A.L., Janda, K.D., "Shedding light on the Ghrelin/GOAT metabolism saga"
ChemBioChem, 12, 523 (2011)

Salzameda, N.T., Eubanks, L.M., Zakhari, J.S., Tsuchikama, K., DeNunzio, N.J., Allen, K.A., Hixon, M.S., Janda, K.D., "A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action"
Chem. Commun., 47, 1713 (2011)

Hicks, M.J., Bishnu, P.D., Rosenberg, J.B., Davidson, J.T., Moreno, A.Y., Janda, K.D., Wee, S., Koob, G.F., Hackett, N.R., Kaminsky, S.M., Worgall, S., Toth, M., Mezey, J.G., Crystal, R.G., "Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs"
Molecular Therapy, 19(3), 612 (2011)

Garner, A.L., Yu, J., Struss, A.K., Lowery, C.A., Zhu, J., Kim, S.K., Park, J., Mayorov, A.V., Kaufmann, G.F., Kravchenko, V.V., Janda, K.D., "Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation"
Bioorg. Med. Chem. Lett., 21, 2702 (2011)

Pier, C.L., Chen, C., Tepp, W.H., Lin, G., Janda, K.D., Barbieri, J.T., Pellett, S., Johnson, E.A., "Botulinum neurotoxin subtype A2 enters cells faster than subtype A1"
FEBS Letters, 585, 199 (2011)

Garner, A.L., Janda, K.D., "Protein-protein interactions and cancer: Targeting the central dogma"
Curr. Top. Med. Chem., 11, 258 (2011)

Kaufmann, G.F., Park, J., Mayorov,A.V., Kubitz, D.M., Janda, K.D., "Generation of quorum quenching antibodies"
Methods Mol. Biol., 692, 299-311 (2011)

Lowery, C.A., Kaufmann, G.F., Janda, K.D., "Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples"
Methods Mol. Biol., 692, 101-111 (2011)

Stowe, G.N., Janda, K.D., "A Diels-Alder reaction conducted within the parameters of aqueous organocatalysis: Still just smoke and mirrors"
Tetrahedron Lett., 52, 2085 (2011)

Denery, J.R., Nunes, A.A., Hixon, M.S., Dickerson, T.J., Janda, K.D., "Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis"
PLoS Negl. Trop. Dis., 4(10), e834 (2010)

Treweek, J.B., Roberts, A.J., Janda, K.D., "Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic"
Mol. Pharm., 7(6), 2056 (2010)

Garner, A.L., Janda, K.D., "cat-ELCCA: A robust method to monitor the fatty acid acyltransferase activity of Ghrelin O-Acyltransferase (GOAT)"
Angew. Chem. Int. Ed., 49(50), 9630 (2010)

Mayorov, A.V., Willis, B., Di Mola, A., Adler, D., Borgia, J., Jackson, O., Wang, J., Luo, Y., Tang, L., Knapp, R.J., Natarajan, C., Goodnough, M.C., Zilberberg, N., Simpson, L.L., Janda, K.D., "Symptomatic relief of Botulinum Neurotoxin/A intoxication with aminopyridines: A new twist on an old molecule"
ACS Chemical Biology, 5(12), 1183 (2010)

Eubanks, L.M., Silhar, P., Salzameda, N.T., Zakhari, J.S., Xiaochuan, F., Barbieri, J.T., Shoemaker, C.B., Hixon, M.S., Janda, K.D., "Identification of a natural product antagonist against the Botulinum neurotoxin light chain protease"
ACS Med. Chem. Lett., 1, 268 (2010)

Steiniger, S., Janda, K.D., "The good, the bad, and the very bad: A new platform strategy to identify drug targets in cancer stem cells"
Laboratory-Journal.com, (2010)

Lowery, C.A., Salzameda, N.T., Sawada, D., Kaufmann, G.F., Janda, K.D., "Medicinal chemistry as a conduit for the modulation of quorum sensing"
J. Med. Chem., 1, 268 (2010)

Thyagarajan, B., Potian, J.G., Garcia, C.C., Hognason, K., Capkova, K., Moe, S.T., Jacobson, A.R., Janda, K.D., McArdle, J.J., "Effects of hydroxamate mettalloprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions"
Neuropharmacology, 58, 1189 (2010)

Moreno, A.Y., Azar, M.R., Warren, N.A., Dickerson, T.J., Koob, G.F., Janda, K.D., "A critical evaluation of a nicotine vaccine within a self-administration behavioral model"
Molecular Pharmaceutics, 7(2), 431 (2010)

Staflin, K., Krueger, J.S., Hachman, J., Forsyth, J.S., Lorger, M., Steiniger, S.C.J., Mee, J., Pop, C., Salvesen, G.S., Janda, K.D., Felding-Habermann, B., "Targeting activated integrin alpha-v-beta-3 with patient-derived antibodies impacts late-stage multiorgan metastasis"
Clin. Exp. Metastasis, 27(4), 217 (2010)

Gloeckner, C., Garner, A., Mersha, F., Oksov, Y., Tricoche, N., Eubanks, L., Lustigman, S., Kaufmann, G., Janda, K.D., "Repositioning of an old drug for the neglected tropical disease Onchocerciasis"
PNAS, 107(8), 3424 (2010)

Silhar, P., Capkova, K., Salzameda, N.T., Barbieri, J.T., Hixon, M.S., Janda, K.D., "Botulinum neurotoxin A protease: Discovery of natural product exosite inhibitors"
J. Am. Chem. Soc., 132, 2868 (2010)

Stowe, G.N., Silhar, P., Hixon, M.S., Silvaggi, N.R., Allen, K.N., Moe, S.T., Jacobson, A.R., Barbieri, J.T., Janda, K.D., "Chirality holds the key for potent inhibition of the Botulinum Neurotoxin serotype A protease"
Org. Lett., 12(4), 756 (2010)

Nakai, Y., Tepp, W.H., Dickerson, T.J., Johnson, E.A., Janda, K.D., "Toosendanin: Synthesis of the AB-ring and investigations of its anti-Botulinum properties (part II)"
Bioorg. Med. Chem., 18, 1280 (2010)

Fukuchi, K., Steiniger, S.C.J., Deryungina, E., Liu, Y., Lowery, C.A., Gloeckner, C., Zhou, B., Kaufmann, G.F., Quigley, J.P., Janda, K.D., "Inhibition of tumor metastasis: Functional immune modulation of the CUB domain containing protein 1"
Molecular Pharmaceutics, 7(1), 245 (2010)

Capkova, K., Hixon, M.S., Pellet, ., Barbieri, J.T., Johnson, E.A., Janda, K.D., "Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase"
Bioorg. Med. Chem. Lett., 20, 206 (2010)

Lowery, C.A., Park, J., Gloeckner, C., Meijler, M.M., Mueller, R.S., Boshoff, H.I., Ulrich, R.L., Barry III, C.E., Bartlett, D.H., Kravchenko, V.V., Kaufmann, G.F., Janda, K.D., "Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals"
J. Am. Chem. Soc., 131, 14473 (2009)

Lowery, C.A., Abe, T., Park, J., Eubanks, L.M., Sawada, D., Kaufmann, G.F., Janda, K.D., "Revisiting AI-2 quorum sensing inhibitors: Direct comparison of alkyl-DPD analogues and a natural product Fimbrolide"
J. Am. Chem. Soc., 131, 15584 (2009)

Salzameda, N.T., Barbieri, J.T., Janda, K.D., "Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors"
Bioorg. Med. Chem. Lett., 19, 5848 (2009)

Steiniger, S., Janda, K.D., "The good, the bad, and the very bad: A new platform strategy to identify drug targets in cancer stem cells"
BIOforum Europe, 6, 25 (2009)

Capkova, K., Salzameda, N.T., Janda, K.D., "Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins"
Toxicon, 54, 575 (2009)

Pires-Alves, M., Ho, M., Aberle, K.K., Janda, K.D., Wilson, B.A., "Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity"
Toxicon, 53, 392 (2009)

Fischer, ., Nakai, Y., Eubanks, L.M., Clancy, C.M., Tepp, W.H., Pellett, S., Dickerson, T.J., Johnson, E.A., Janda, K.D., Montal, M., "Bimodal modulation of the botulinum neurotoxin protein-conducting channel"
PNAS, 106, 1330 (2009)

Treweek, J.B., Moreno, A.Y., Janda, K.D. , "SLEEPLESS-ness and insomnia in fruit flies"
Angew. Chem. Int. Ed., 48, 438 (2009)

Treweek, J.B., Dickerson, T.J., Janda, K.D., "Drugs of abuse that mediate advanced glycation end product formation: A chemical link to disease pathology"
Accounts of Chemical Research, 42(5), 659 (2009)

Frederick, M.O., De Lamo Marin, S., Janda, K.D., Nicolaou, K.C., Dickerson, T.J., "Monoclonal antibodies with orthoganal azaspiracid epitopes"
ChemBioChem, 10, 1625 (2009)

Moreno, A.Y., Janda, K.D., "Immunopharmacotherapy: Vaccination stratagies as a treatment for drug abuse and dependence"
Pharmacology, Biochemistry, and Behavior, 92, 199 (2009)

Nakai, Y., Tepp, W.H., Dickerson, T.J., Johnson, E.A., Janda, K.D., "Function-oriented synthesis applied to the anti-botulinum natural product toosendanin"
Bioorg. Med. Chem., 17, 1152 (2009)

Zhou, H., Zhou, B., Pellett, S., Johnson, E.A., Janda, K.D., "Selection and characterization of a human monoclonal neutralizing antibody for Clostridium Botulinum neurotoxin serotype B"
Bioorg. Med. Chem. Lett., 19, 662 (2009)

Sheng, J., Oyler, G., Zhou, B., Janda, K., Shoemaker, C.B., "Identification and characterization of a novel cell-penetrating peptide"
Biochemical and Biophysical Research Coomunications, 382, 236 (2009)

Brogan, A.P., Dickerson, T.J., Janda, K.D., "Catalytic Antibodies (Abzymes), Synthetic"
Wiley Encyclopedia of Chemical Biology, (2008)

Treweek, J.B., Sun, C., Mayorov, A.V., Qi, L., Levy, C.L., Roberts, A.J., Dickerson, T.J., Janda, K.D., "Prevention of drug-induced memory impairment by immunopharmacotherapy"
J. Med. Chem., 51, 6866 (2008)

Willis, B., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "The strange case of the Botulinum neurotoxin: Using chemistry and biology to modulate the most deadly poison"
Angew. Chem. Int. Ed., 47, 8360 (2008)

Mayorov, A.V., Amara, N., Chang, J.Y., Moss, J.A., Hixon, M.S., Ruiz, D.I., Meijler, M.M., Zorilla, E.P., Janda, K.D., "Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice"
PNAS, 105(45), 17487 (2008)

Steiniger, S.C.J., Coppinger, J.A., Kruger, J.A., Yates III, J., Janda, K.D., "Quantitative mass spectrometry identifiies drug targets in cancer stem cell containing side population"
Stem Cells, 26(12), 3037 (2008)

Park, J., Dickerson, T.J., Janda, K.D., "Major sperm protein as a diagnostic antigen for onchocerciasis"
Bioorg. Med. Chem., 16, 7206 (2008)

Capkova, K., Hixon, M.S., McAllister,L.A., Janda, K.D., "Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations"
Chem. Commun., 3525 (2008)

Park, J., Kaufmann, G.F., Bowen, J.P., Arbiser, J.L., Janda, K.D., " Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aerginosa"
JID, 198, 1198 (2008)

Lowery, C.A., Park, J., Kaufmann, G.F., Janda, K.D., "An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-Dihydroxy-2,3-pentanedione analogues"
J. Am. Chem. Soc., 130(29), 9200 (2008)

Lowery, C.A., Dickerson, T.J., Janda, K.D., "Interspecies and interkingdom communication mediated by bacterial quorum sensing"
Chem. Soc. Rev., 37(7), 1337 (2008)

Kravchenko, V.V., Kaufmann, G.F., Mathison, J.C., Scott, D.A., Katz, A.Z., Grauer, D.C., Lehmann, M., Meijler, M.M., Janda, K.D., Ulevitch, R.J., "Modulation of gene expression via disruption of NF-kB signaling by a bacterial small molecule"
Science, 321, 259 (2008)

Debler, E.W., Kaufmann, G.F., Meijler, M.M., Heine, A., Mee, J.M., Pljevaljcic, G., Di Bilio, A.J., Schultz, P.G., Millar, D.P., Janda, K.D., Wilson, I.A., Gray, H.B., Lerner, R.A., "Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex"
Science, 319(5867), 1232 (2008)

Kaufmann, G.F., Park, J., Janda, K.D., "Bacterial quorum sensing: a new target for anti-infective immunotherapy"
Expert Opin. Biol. Ther., 8(6), 719 (2008)

Zhou, B., Pellett, S., Tepp, W.H., Zhou, H., Johnson, E.A., Janda, K.D., "Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects"
FEBS Letters, 582, 1526 (2008)

Kaufmann, G.F., Park, J., Mee, J.M., Ulevitch, R.J., Janda, K.D., "The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone"
Molecular Immunology, 45, 2710 (2008)

Yoneda, Y., Steiniger, S.C.J., Capkova, K., Mee, J.M., Liu, Y., Kaufmann, G.F., Janda, K.D., "A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy"
Bioorg. Med. Chem. Lett., 18, 1632 (2008)

Zhou, B., Carney, C., Janda, K.D., "Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin"
Bioorg. Med. Chem., 16, 1903 (2008)

Willis, B., Eubanks, L.M., Wood, M.R., Janda, K.D., Dickerson, T.J., Lerner, R.A.L., "Biologically templated organic polymers with nanoscale order"
PNAS, 105(5), 1416 (2008)

Zarebski, L.M., Vaughan, K., Sidney, J., Peters, B., Grey, H., Janda, K.D., Casadevall, A., Sette, A., "Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum"
Expert Rev. Vaccines, 7(1), 55 (2008)

Richardson, H.N., Zhao, Y., Fekete, E.M., Funk, C.K., Wirsching, P., Janda, K.D., Zorrilla, E.P., Koob, G.F., "MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist"
Pharmacology, Biochemistry and Behavior, 88, 497 (2008)

Brogan, A.P., Dickerson, T.J., Janda, K.D., "Nornicotine-organocatalyzed aqueous reduction of alpha, beta-unsaturated aldehydes"
Chem. Commun., 46, 4952 (2007)

Dickerson, T.J., McKenzie, K.M., Hoyt, A.S., Wood, M.R., Janda, K.D., Brenner, S.B., Lerner, R.A., "Phage escape libraries for checkmate analysis"
PNAS, 104(31), 12703 (2007)

Zhou, H., Zhou, B., Ma, H., Carney, C., Janda, K.D.,, "Selection and characterization of human monoclonal antibodies against Abrin by phage display"
Bioorg. Med. Chem. Lett., 17, 5690 (2007)