Sajish Mathew, Ph.D.
Contact: sthekkel@scripps.edu
Education:
Ph. D - Indian Institute of Technology (IIT) Kanpur, May 2009
M. Sc - University of Calicut, Kerala, India, June 2003
B. Sc - Kannur University, Kerala, India, June 2000
Research:
My interest is to understand the molecular basis of diseases caused by metabolic dysfunction like diabetes, cancer and Alzheimer’s disease. My current focus is on the non-translational functions of aminoacyl tRNA synthetases (the amino acid binding proteins) to understand how the amino acids are involved in glucose homeostasis. We believe that elucidation of the functional role of aminoacyl tRNA synthetases in the regulation of metabolic flux will shed light on the etiology of various metabolic diseases and will provide novel strategies to tackle metabolic dysfunctions.
Publications:
Mathew Sajish, Quansheng Zhou, Shuji Kishi, Delgado M Valdez Jr, Mili Kapoor, Min Guo, Sunhee Lee, Sunghoon Kim, Xiang-Lei Yang and Paul Schimmel (2012). Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nature Chem. Bio. 8: 547–554.
Mathew Sajish, Sissy Kalayil, Sunil Kumar Verma, Vinay Kumar Nadicoori and Balaji Prakash (2009). The Significance of ExDD and RxKD Motifs Conservation in Rel Proteins. J. Biol. Chem. 284: 9115-9123.
Mathew Sajish, Divya Tiwari, Dimple Rananaware, Vinay Kumar Nadicoori and Balaji Prakash (2007). A Charge Reversal Differentiates (p)ppGpp Synthesis by Monofunctional and Bifunctional Rel Proteins. J. Biol. Chem. 282: 34977-34983.
Awards/Fellowships:
- National Doctoral Fellowship (NDF) by All India Council of Technical Education (AICTE) 2004.
- Joint Council of Scientific and Industrial Research (CSIR) and University Grants Commission (UGC) – National Eligibility Test (NET) for lectureship and Junior Research Fellowship (JRF) - June 2002.
- Graduate Aptitude Test in Engineering (GATE) - 2002 with 97 percentile and All India Rank 72
- Joint Council of Scientific and Industrial Research (CSIR) and University Grants Commission (UGC) – National Eligibility Test (NET) for lectureship and Junior Research Fellowship (JRF) - December 2001.
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